What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Bempedoic Acid + Vitamin C pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·a caution·Emerging evidence

Bempedoic Acid + Vitamin C

Q: Can I take Bempedoic Acid and Vitamin C together?

Possibly, but with caution. Bempedoic Acid and Vitamin C have a documented caution-tier interaction. Bempedoic acid can raise serum uric acid by competing with uric acid for renal tubular secretion via OAT2, and gout has been reported as an adverse effect. High-dose vitamin C (typically several grams per day) has a uricosuric effect that lowers serum uric acid. While this could theoretically offset bempedoic-acid-induced hyperuricemia, very high vitamin C intake also increases urinary oxalate and uric acid excretion, which can promote kidney stones in susceptible individuals. The interaction is minor and not a reason to avoid either agent.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Caution Emerging evidence

Bempedoic acid can raise serum uric acid by competing with uric acid for renal tubular secretion via OAT2, and gout has been reported as an adverse effect. High-dose vitamin C (typically several grams per day) has a uricosuric effect that lowers serum uric acid. While this could theoretically offset bempedoic-acid-induced hyperuricemia, very high vitamin C intake also increases urinary oxalate and uric acid excretion, which can promote kidney stones in susceptible individuals. The interaction is minor and not a reason to avoid either agent.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Bempedoic Acid and Vitamin C

Pair type

Caution

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

CautionEmerging evidence

What is happening. Bempedoic acid can raise serum uric acid by competing with uric acid for renal tubular secretion via OAT2, and gout has been reported as an adverse effect. High-dose vitamin C (typically several grams per day) has a uricosuric effect that lowers serum uric acid. While this could theoretically offset bempedoic-acid-induced hyperuricemia, very high vitamin C intake also increases urinary oxalate and uric acid excretion, which can promote kidney stones in susceptible individuals. The interaction is minor and not a reason to avoid either agent.

Mechanism. Bempedoic acid inhibits renal OAT2-mediated tubular secretion of uric acid, reducing urate clearance and raising serum levels. High-dose vitamin C has an opposing uricosuric action but increases urinary urate and oxalate load. The two interact only at the level of renal urate handling, not through hepatic metabolism.

Recommendation. Normal dietary or low-dose supplemental vitamin C is fine with bempedoic acid. If you take gram-level vitamin C and have gout, hyperuricemia, or a history of kidney stones, discuss this with your clinician, since both bempedoic acid (raising uric acid) and high-dose vitamin C (increasing urinary uric acid/oxalate) act on renal urate handling. Periodic uric acid monitoring is reasonable while on bempedoic acid.

Stack Score

How it moves the number.

Effect on the composite score

If both Bempedoic Acid and Vitamin C are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Nissen SE, et al. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients (CLEAR Outcomes). N Engl J Med. 2023.Needs sourceNo link
2Huang HY, et al. The effects of vitamin C supplementation on serum concentrations of uric acid: a systematic review and meta-analysis of randomized controlled trials. Arthritis Rheum. 2005.Needs sourceNo link

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