From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Berberine may add modest lipid-lowering effects to Bempedoic Acid.
Mechanism. Pharmacodynamic additivity through complementary LDL cholesterol, triglyceride, bile acid, or glycemic pathways.
Recommendation. Use as part of the lipid plan, not as a substitute for prescribed therapy; recheck lipids after regimen changes.
Stack Score
How it moves the number.
Effect on the composite score
If both Bempedoic Acid and Berberine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Clinical lipid guideline and supplement evidence reviews.Needs sourceNo link