Supplement × Supplement·contraindicated·Emerging evidence
Berberine can lower glucose and IGF-1 LR3 may cause insulin-like glucose lowering, increasing hypoglycemia risk.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Berberine can lower glucose and IGF-1 LR3 may cause insulin-like glucose lowering, increasing hypoglycemia risk.
Mechanism. Additive glucose-lowering through AMPK and insulin/IGF receptor-related pathways.
Recommendation. Do not combine; avoid human IGF-1 LR3 use altogether.
Effect on the composite score
If both Berberine and IGF-1 LR3 (Long R3 IGF-1) are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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