From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
ContraindicatedInsufficient evidence
What is happening. Alpha-lipoic acid may lower glucose and could add to IGF-1 LR3-related hypoglycemia risk.
Mechanism. Additive insulin-sensitizing and IGF receptor-mediated glucose uptake effects.
Recommendation. Do not combine; seek medical care for hypoglycemia symptoms after any exposure.
Stack Score
How it moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and IGF-1 LR3 (Long R3 IGF-1) are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Thevis M et al. Detection of Long-R3-IGF-I in black market product. Drug Test Anal. 2010.Needs sourceNo link