NutriStack
Nicotine and Vitamin C, a caution.
Nicotine and smoking markedly increase oxidative stress and lower plasma vitamin C levels, so nicotine users often have depleted vitamin C status.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Nicotine and smoking markedly increase oxidative stress and lower plasma vitamin C levels, so nicotine users often have depleted vitamin C status.
Mechanism. Nicotine and tobacco smoke generate reactive oxygen species and increase metabolic turnover of ascorbate, lowering circulating and tissue vitamin C concentrations.
Recommendation. Do not use nicotine. For those who do, vitamin C stores are likely depleted, but supplementation does not offset nicotine's harms; addressing nicotine use itself is the priority.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Nicotine and Vitamin C are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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