Social isolation at adolescence: a systematic review on behaviour related to cocaine, amphetamine and nicotine use in rats and mice.
Systematic ReviewAnimal study
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
Supplement × Prescription·Evidence index
PubMed indexes 8 records that name Amphetamine/Dextroamphetamine and Nicotine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Amphetamine/Dextroamphetamine and Nicotine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
“The effects of both amphetamine and nicotine did not differ by sex for either drug. Overall, these results suggest that the mechanisms mediating the addictive qualities of these drugs and their appetite suppressing effects may be distinct and therefore could be a potential target for future obesity therapeutics.”
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
“The effects of both amphetamine and nicotine did not differ by sex for either drug. Overall, these results suggest that the mechanisms mediating the addictive qualities of these drugs and their appetite suppressing effects may be distinct and therefore could be a potential target for future obesity therapeutics.”
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
“Chronic treatment with AMPH or NIC boosts cognitive performance in adult zebrafish. Cognitive sensitization occurred with both drugs, resulting in enhanced working memory; however, repeat AMPH exposure, following a withdrawal period, resulted in inhibited cognitive flexibility, an effect not evident with repeat NIC exposure.”
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
“A nicotine concentration of 50 nM is comparable to brain nicotine levels experienced by chronic smokers over long periods of time. Taken together, these data indicate that nicotine may exert some of its actions through the regulation of CART transcription in the brain.”
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
“Secondly, injection stress itself may have been sufficient to induce plastic changes in dopamine and glutamate systems, and these changes enhanced the acquisition and maintenance of nicotine self-administration. Further investigation is needed into the role of stress in the development of nicotine use and dependence, in the aetiology of schizophrenia and in their co-morbidity.”
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
“These findings indicate that environmental enrichment can limit the ability of adolescent nicotine exposure to increase vulnerability to other psychostimulant drugs, such as d-amphetamine. (PsycINFO Database Record”
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
“Together, these results demonstrate that nicotine reduces reward-associated behaviors following repeated amphetamine and modifies the changes in ChIs firing and corticostriatal activity. By returning glutamatergic activity in amphetamine self-administering mice to a more stable and normalized state, nicotine limits the depression of striatal activity in withdrawal and the increase in activity following abstinence and a subsequent drug challenge.”
Names both Amphetamine/Dextroamphetamine and Nicotine in its title.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Amphetamine/Dextroamphetamine, Nicotine, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.