Supplement × Prescription·Evidence index
PubMed indexes 8 records that name Amphetamine/Dextroamphetamine and Vitamin C together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Amphetamine/Dextroamphetamine and Vitamin C. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
“Amphetamine-induced increases in uric acid were more nearly dose-related than changes in ascorbic acid. Of the two compounds, uric acid seems more likely to be associated with dopamine.”
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
“Compared to the traditionally used high-dose regimens, these effects were mild but in the same direction. The advantage of this regimen is that it better reflects amphetamine-induced depletions of dopamine in humans.”
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
“These results suggest that d-amphetamine-induced increases in AA and uric acid and decreases in glutamate concentrations are triggered at nigral sites. The changes in aspartate levels may be evoked by at least two mechanisms: striatal (mediated by inhibitory dopaminergic receptors) and nigral (activation of amino acid carrier-mediated uptake).”
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
“On the contrary, it did not alter the pattern of reverse tolerance to increased locomotor activity. The results suggest that modulation of dopamine receptor sensitivity by ascorbic acid may be the reason for the delay in development of tolerance to amphetamine induced anorexia.”
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
“Further, AA oxidation occurs in the extracellular space. The cortico-striatal glutamatergic pathways exert an inhibitory modulation on d-amphetamine behavioral effects.”
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
“In remaining brain, apomorphine (single) and d-amphetamine (repeated) treatment increased DHAA/AA ratio; such increase was observed also when haloperidol was associated with apomorphine or d-amphetamine; moreover, haloperidol by itself increased AA oxidation, although to a lesser extent than it did in hypothalamus.”
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
“Furthermore, in the nucleus accumbens the amphetamine-induced increase in AA was very similar on all test days, but in the caudate the increase in AA produced by 5 mg/kg amphetamine was progressively larger on each test day. Thus AA seems to be regulated differently in the caudate and nucleus accumbens.”
Names both Amphetamine/Dextroamphetamine and Vitamin C in its title.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Amphetamine/Dextroamphetamine, Vitamin C, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
