NutriStack
Amphetamine/Dextroamphetamine and Cocaine, contraindicated.
Cocaine and amphetamine/dextroamphetamine are both sympathomimetic stimulants. Using them together can intensify tachycardia, hypertension, coronary vasospasm, overheating, anxiety, and arrhythmia risk. The danger is higher with high stimulant doses, dehydration, strenuous activity, or any history of heart disease, high blood pressure, panic attacks, or stimulant use disorder.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Amphetamine/Dextroamphetamine and Cocaine
- Pair type
- Contraindicated
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Moderate evidence
Contraindicated
What is happening. Cocaine and amphetamine/dextroamphetamine are both sympathomimetic stimulants. Using them together can intensify tachycardia, hypertension, coronary vasospasm, overheating, anxiety, and arrhythmia risk. The danger is higher with high stimulant doses, dehydration, strenuous activity, or any history of heart disease, high blood pressure, panic attacks, or stimulant use disorder.
Mechanism. Cocaine blocks dopamine, norepinephrine, and serotonin reuptake and also has sodium-channel blocking effects. Amphetamine/dextroamphetamine increases catecholamine release through DAT and NET, so the combination can produce additive adrenergic stimulation and myocardial oxygen demand.
Recommendation. Do not use cocaine while taking amphetamine/dextroamphetamine. If cocaine exposure occurs, do not take extra stimulant doses and avoid exercise or overheating. Seek emergency care for chest pain, fainting, severe headache, severe agitation, shortness of breath, or a racing or irregular heartbeat.
Sources (2)
- Rush CR, Stoops WW, Hays LR. Cocaine effects during D-amphetamine maintenance: a human laboratory analysis of safety, tolerability and efficacy. Drug Alcohol Depend. 2009;99(1-3):261-271. PMID 18926645
- Kim ST, Park T. Acute and Chronic Effects of Cocaine on Cardiovascular Health. Int J Mol Sci. 2019;20(3):584. PMID 30700023
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amphetamine/Dextroamphetamine and Cocaine are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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