NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Amphetamine/Dextroamphetamine and Cocaine: what the published research says

PubMed indexes 8 records that name Amphetamine/Dextroamphetamine and Cocaine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Amphetamine/Dextroamphetamine and Cocaine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Amphetamine/Dextroamphetamine and Cocaine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Decreased Serum Cocaine- and Amphetamine-Regulated Transcript Level in Internet Gaming Disorder.

Psychiatry investigation · 2024 · PMID 39089701

“Our results indicate that a decrease in the expression of the serum CART level is associated with the vulnerability of developing IGD. This study supports the possibility that CART is a biomarker in the pathophysiology of IGD.”

Cho et al. · Authors' conclusion

Names both Amphetamine/Dextroamphetamine and Cocaine in its title.

Effect of Cocaine, Amphetamine, and Cannabis Use Disorders on 30-day Readmissions of Patients with Heart Failure.

Current problems in cardiology · 2023 · PMID 35346722

ReviewHuman subjects

“In conclusion, HF patients with SUD have an elevated risk of 30-day all-cause readmissions, mainly driven by cocaine and other stimulant disorders. Screening for substance use in hospitalized HF patients as well as timely referral for treatment are important to prevent HF readmissions.”

Thyagaturu et al. · From the abstract

Names both Amphetamine/Dextroamphetamine and Cocaine in its title.

D-amphetamine maintenance therapy reduces cocaine use in female rats.

Psychopharmacology · 2022 · PMID 36357743

ReviewHuman subjects

“D-amphetamine treatment can both prevent and reverse increases in the motivation to take and seek cocaine in female animals.”

Ndiaye et al. · Authors' conclusion

Names both Amphetamine/Dextroamphetamine and Cocaine in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Amphetamine/Dextroamphetamine, Cocaine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.