Supplement × Supplement·a caution·Insufficient evidence

Berberine + GHRP-6

Caution Insufficient evidence

Berberine affects glucose while GHRP-6 may worsen glucose tolerance and increase appetite.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Caution
Evidence
Insufficient
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence

What is happening. Berberine affects glucose while GHRP-6 may worsen glucose tolerance and increase appetite.

Mechanism. Glucose-lowering supplement effects plus GH/ghrelin-axis metabolic effects.

Recommendation. Do not use berberine to compensate for unapproved peptide-related glucose effects; monitor medically.

Stack Score

How it moves the number.

Effect on the composite score

If both Berberine and GHRP-6 are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Cabrales A et al. GHRP-6 pharmacokinetic study. Eur J Pharm Sci. 2013.Needs sourceNo link

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