From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Berberine affects glucose while GHRP-6 may worsen glucose tolerance and increase appetite.
Mechanism. Glucose-lowering supplement effects plus GH/ghrelin-axis metabolic effects.
Recommendation. Do not use berberine to compensate for unapproved peptide-related glucose effects; monitor medically.
Stack Score
How it moves the number.
Effect on the composite score
If both Berberine and GHRP-6 are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Cabrales A et al. GHRP-6 pharmacokinetic study. Eur J Pharm Sci. 2013.Needs sourceNo link