From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionInsufficient evidence
What is happening. Berberine may lower glucose while hexarelin can alter GH-axis glucose regulation.
Mechanism. Glucose-lowering supplement effects plus GH secretagogue effects.
Recommendation. Avoid unsupervised stacking and monitor glucose in any medically supervised context.
Stack Score
How it moves the number.
Effect on the composite score
If both Berberine and Hexarelin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Arvat E et al. Hexarelin dose-response study. JCEM. 1996.Needs sourceNo link