NutriStack
Berberine HCl and Coenzyme Q10, a caution.
Berberine HCl may inhibit mitochondrial Complex I, similar to metformin. CoQ10 supplementation may help offset potential mitochondrial effects.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Berberine HCl and Coenzyme Q10
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Berberine HCl may inhibit mitochondrial Complex I, similar to metformin. CoQ10 supplementation may help offset potential mitochondrial effects.
Mechanism. Berberine HCl partially inhibits mitochondrial Complex I (NADH:ubiquinone oxidoreductase), which may explain its AMPK activation. CoQ10 supports electron transport and may mitigate this inhibition.
Recommendation. Consider adding CoQ10 when taking berberine hcl long-term to support mitochondrial function.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine HCl and Coenzyme Q10 are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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