NutriStack
Calcium and Carbamazepine, a synergy.
Long-term carbamazepine therapy is associated with adverse bone-mineral effects and higher fracture risk, especially when vitamin D or calcium intake is low. Calcium intake is part of standard bone-health prevention for people on chronic antiseizure medication. This is a long-term risk issue rather than an acute same-day interaction.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Calcium and Carbamazepine
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Long-term carbamazepine therapy is associated with adverse bone-mineral effects and higher fracture risk, especially when vitamin D or calcium intake is low. Calcium intake is part of standard bone-health prevention for people on chronic antiseizure medication. This is a long-term risk issue rather than an acute same-day interaction.
Mechanism. Carbamazepine induces hepatic enzymes and is linked with altered vitamin D and bone turnover markers, which can reduce calcium absorption and weaken bone over time. Adequate calcium supports mineralization but does not correct all carbamazepine-related bone risk by itself.
Recommendation. Make sure your total calcium intake from diet and supplements is appropriate while taking carbamazepine long term. Ask about vitamin D testing and bone-density screening if you have additional fracture risks. Do not take very high calcium doses unless prescribed because excess calcium can raise kidney-stone and cardiovascular concerns in some people.
Sources (2)
- Erbayat Altay E, Serdaroglu A, Tumer L, Gucuyener K, Hasanoglu A. Evaluation of bone mineral metabolism in children receiving carbamazepine and valproic acid. J Pediatr Endocrinol Metab. 2000;13(7):933-939. PMID 10968482
- Lazzari AA, Dussault PM, Thakore-James M, Gagnon D, Baker E, Davis SA, et al. Prevention of bone loss and vertebral fractures in patients with chronic epilepsy--antiepileptic drug and osteoporosis prevention trial. Epilepsia. 2013;54(11):1997-2004. PMID 24010637
Stack Score
How this pair moves the number.
Effect on the composite score
If both Calcium and Carbamazepine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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