NutriStack
Chromium and Liraglutide, a caution.
Liraglutide is a daily GLP-1 receptor agonist used for type 2 diabetes and weight management. Chromium improves insulin sensitivity. On liraglutide alone, hypoglycemia is uncommon, but additive glucose-lowering can become clinically meaningful when chromium is layered on top of a regimen that also includes insulin or a sulfonylurea.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Chromium and Liraglutide
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Liraglutide is a daily GLP-1 receptor agonist used for type 2 diabetes and weight management. Chromium improves insulin sensitivity. On liraglutide alone, hypoglycemia is uncommon, but additive glucose-lowering can become clinically meaningful when chromium is layered on top of a regimen that also includes insulin or a sulfonylurea.
Mechanism. Liraglutide activates GLP-1 receptors, increasing glucose-dependent insulin release, suppressing glucagon, and slowing gastric emptying. Chromium enhances insulin receptor tyrosine kinase activity and GLUT4 translocation. The two produce additive glucose-lowering.
Recommendation. If liraglutide is your only diabetes medication, chromium can be added with home glucose monitoring for the first 2-4 weeks. If you also take insulin or a sulfonylurea, ask your prescriber whether those agents need to be reduced first.
Sources (2)
- Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther. 2006;8(6):636-43. PMID 17109595
- Havel PJ. A scientific review: the role of chromium in insulin resistance. Diabetes Educ. 2004;Suppl:2-14. PMID 15208835
Stack Score
How this pair moves the number.
Effect on the composite score
If both Chromium and Liraglutide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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