NutriStack
Berberine and Liraglutide, a caution.
Both liraglutide and berberine lower blood glucose. Both also slow GI motility, compounding GI side effects (nausea, vomiting, diarrhea). Significant hypoglycemia risk when combined.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Berberine and Liraglutide
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both liraglutide and berberine lower blood glucose. Both also slow GI motility, compounding GI side effects (nausea, vomiting, diarrhea). Significant hypoglycemia risk when combined.
Mechanism. Liraglutide activates GLP-1 receptors, enhancing insulin secretion and slowing gastric emptying. Berberine activates AMPK. Both slow GI motility independently.
Recommendation. Monitor glucose closely. GI side effects may be additive. Start berberine at low dose if combining.
Sources (2)
- Marso SP et al. Liraglutide and cardiovascular outcomes in type 2 diabetes (LEADER). N Engl J Med. 2016;375(4):311-322. PMID 27295427
- Asbaghi O, Ghanbari N, Shekari M et al.. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials.. Clinical Nutrition ESPEN. 2020. PMID 32690176
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine and Liraglutide are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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