NutriStack
Citicoline and Magnesium L-Threonate, a synergy.
Both cross the blood-brain barrier to support cognitive function. Magnesium enhances synaptic plasticity; citicoline supports membrane phospholipid synthesis.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Citicoline and Magnesium L-Threonate
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Both cross the blood-brain barrier to support cognitive function. Magnesium enhances synaptic plasticity; citicoline supports membrane phospholipid synthesis.
Mechanism. Magnesium L-threonate increases brain Mg²⁺, enhancing LTP (long-term potentiation) at hippocampal synapses. Citicoline provides building blocks for phosphatidylcholine in neuronal membranes.
Recommendation. Effective nootropic combination for memory, focus, and brain health.
Sources (1)
- Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010
Stack Score
How this pair moves the number.
Effect on the composite score
If both Citicoline and Magnesium L-Threonate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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