NutriStack
Citicoline and Lion's Mane, a synergy.
Lion's mane promotes nerve growth factor (NGF) synthesis while citicoline supports phospholipid membrane synthesis. Complementary nootropic stack.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Citicoline and Lion's Mane
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Lion's mane promotes nerve growth factor (NGF) synthesis while citicoline supports phospholipid membrane synthesis. Complementary nootropic stack.
Mechanism. Hericenones and erinacines from lion's mane cross the BBB and stimulate NGF synthesis. Citicoline provides choline for acetylcholine and cytidine for neuronal membrane phospholipid repair.
Recommendation. Combine for comprehensive cognitive support, neurogenesis (lion's mane) + membrane integrity (citicoline).
Sources (1)
- Mori K et al. Improving effects of the mushroom Hericium erinaceus on mild cognitive impairment. Phytother Res. 2009
Stack Score
How this pair moves the number.
Effect on the composite score
If both Citicoline and Lion's Mane are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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