NutriStack
Alpha-GPC and Lion's Mane, a synergy.
Lion's mane promotes NGF for neuroplasticity while Alpha-GPC provides choline for acetylcholine synthesis. Synergistic cognitive enhancement.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alpha-GPC and Lion's Mane
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Lion's mane promotes NGF for neuroplasticity while Alpha-GPC provides choline for acetylcholine synthesis. Synergistic cognitive enhancement.
Mechanism. Lion's mane erinacines stimulate NGF, promoting neuronal growth and myelination. Alpha-GPC crosses BBB to provide choline for ACh synthesis. NGF also upregulates choline acetyltransferase.
Recommendation. Effective nootropic combination for memory and focus. Lion's mane 500-1000mg + Alpha-GPC 300-600mg.
Sources (2)
- Parker AG et al. The effects of alpha-glycerylphosphorylcholine on cognitive function. J Int Soc Sports Nutr. 2015
- Sagaro GG, Traini E, Amenta F. Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2023. PMID 36683513
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-GPC and Lion's Mane are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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