What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Lion's Mane + Magnesium L-Threonate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × SupplementReviewed May 2026

Lion's Mane and Magnesium L-Threonate, a synergy.

Q: Can I take Lion's Mane and Magnesium L-Threonate together?

Yes. The combination of Lion's Mane and Magnesium L-Threonate produces a measurable benefit. Both support neuroplasticity through different mechanisms. Magnesium L-threonate enhances synaptic density; lion's mane promotes NGF synthesis.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Both support neuroplasticity through different mechanisms. Magnesium L-threonate enhances synaptic density; lion's mane promotes NGF synthesis.

1 primary source citation. Emerging evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Lion's Mane and Magnesium L-Threonate
Pair type: Synergy
Evidence (highest tier): Emerging
Source citations: 1 source
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Supplement
Last verified: May 30, 2026

Synergy · Emerging evidence

Synergy

What is happening. Both support neuroplasticity through different mechanisms. Magnesium L-threonate enhances synaptic density; lion's mane promotes NGF synthesis.

Mechanism. Brain magnesium (via L-threonate) increases NR2B-containing NMDA receptor density at synapses. Lion's mane erinacines stimulate NGF, promoting neuronal survival and axonal growth. Synergistic neuroplasticity.

Recommendation. Combine for comprehensive cognitive enhancement and neuroprotection.

Sources (1)

Slutsky I et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010

Stack Score

How this pair moves the number.

Effect on the composite score

If both Lion's Mane and Magnesium L-Threonate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

Check your full routine

One pair was the worked example. NutriStack runs every pair in your stack at once.

Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.

Open the interaction checker →Browse the full research index