Supplement × Prescription·contraindicated·Moderate evidence
St. John's Wort can add serotonergic activity and can alter metabolism of many drugs.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort can add serotonergic activity and can alter metabolism of many drugs.
Mechanism. Additive serotonin effects increase serotonin syndrome risk; enzyme induction can destabilize other therapy.
Recommendation. Do not combine St. John's Wort with clomipramine.
Effect on the composite score
If both Clomipramine and St. John's Wort are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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