NutriStack
Clonazepam and Passionflower, a caution.
Passionflower can have calming CNS effects and GABA-related activity. Clonazepam is a long-acting benzodiazepine, so additive sedation may last longer than expected and may carry into the next day. This is more concerning in older adults, people with sleep apnea, and anyone also using alcohol, opioids, antihistamines, or sleep medicines.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Clonazepam and Passionflower
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Passionflower can have calming CNS effects and GABA-related activity. Clonazepam is a long-acting benzodiazepine, so additive sedation may last longer than expected and may carry into the next day. This is more concerning in older adults, people with sleep apnea, and anyone also using alcohol, opioids, antihistamines, or sleep medicines.
Mechanism. Passionflower extract has demonstrated GABA(A)-linked activity and clinical anxiolytic effects. Clonazepam enhances GABA(A) receptor signaling, so the combination can produce additive CNS depression.
Recommendation. Do not add passionflower to clonazepam without prescriber guidance. If the combination is approved, avoid driving or hazardous work until you know the effect and stop the supplement if excessive sleepiness, confusion, unsteady gait, or falls occur. Seek urgent care for severe sedation or breathing problems.
Sources (2)
- Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther. 2001;26(5):363-367. PMID 11679026
- Elsas SM, Rossi DJ, Raber J, White G, Seeley CA, Gregory WL, et al. Passiflora incarnata L. extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomedicine. 2010;17(12):940-949. PMID 20382514
Stack Score
How this pair moves the number.
Effect on the composite score
If both Clonazepam and Passionflower are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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