NutriStack
Clonazepam and Valerian Root, a caution.
Both clonazepam and valerian act on GABA-A receptors. Combined use causes additive CNS depression, excessive sedation, and respiratory depression risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Clonazepam and Valerian Root
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both clonazepam and valerian act on GABA-A receptors. Combined use causes additive CNS depression, excessive sedation, and respiratory depression risk.
Mechanism. Clonazepam binds benzodiazepine site on GABA-A receptors. Valerenic acid also modulates GABA-A. Dual allosteric modulation causes excessive CNS depression.
Recommendation. Avoid combining. If using valerian, do not take with clonazepam. Additive sedation can be dangerous.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Clonazepam and Valerian Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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