NutriStack
Diazepam and Valerian Root, a caution.
Both diazepam and valerian enhance GABA-A receptor activity. Combined use creates additive CNS depression and excessive sedation.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Diazepam and Valerian Root
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both diazepam and valerian enhance GABA-A receptor activity. Combined use creates additive CNS depression and excessive sedation.
Mechanism. Diazepam binds the benzodiazepine allosteric site on GABA-A receptors. Valerenic acid modulates GABA-A receptors at a different site. Dual enhancement of GABAergic transmission causes excessive inhibition.
Recommendation. Avoid combining valerian with diazepam. The additive sedative effect can impair breathing and cause excessive drowsiness.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Diazepam and Valerian Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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