NutriStack
Ketamine and Valerian Root, a caution.
Valerian root has sedative-hypnotic activity that can add to ketamine's central depressant and dissociative effects, increasing drowsiness, dizziness, and impaired reaction time.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Ketamine and Valerian Root
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Valerian root has sedative-hypnotic activity that can add to ketamine's central depressant and dissociative effects, increasing drowsiness, dizziness, and impaired reaction time.
Mechanism. Valerian constituents modulate GABA-A receptor activity and may slow GABA breakdown, enhancing inhibitory tone that can compound the central nervous system depression produced by ketamine.
Recommendation. Do not combine valerian root with ketamine. If both are in use, avoid driving and other tasks requiring alertness and seek medical advice.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ketamine and Valerian Root are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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