NutriStack
Ketamine and Melatonin, a caution.
Melatonin taken as a sleep aid can add to ketamine's sedating effects, increasing drowsiness and impairing alertness and coordination.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Melatonin taken as a sleep aid can add to ketamine's sedating effects, increasing drowsiness and impairing alertness and coordination.
Mechanism. Melatonin promotes sleep onset and mild central nervous system sedation, which can be additive with ketamine's sedative and dissociative effects and deepen drowsiness.
Recommendation. Do not combine melatonin with ketamine without medical advice. If both are in use, avoid driving and tasks requiring full alertness.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ketamine and Melatonin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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