NutriStack
Alcohol and Ketamine, contraindicated.
Combining ketamine with alcohol produces additive central nervous system and respiratory depression, raising the risk of profound sedation, airway compromise, vomiting with aspiration, and loss of consciousness.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Combining ketamine with alcohol produces additive central nervous system and respiratory depression, raising the risk of profound sedation, airway compromise, vomiting with aspiration, and loss of consciousness.
Mechanism. Both agents depress the central nervous system: alcohol potentiates GABA-A inhibitory tone while ketamine adds NMDA receptor antagonism and dissociation, so the combination compounds sedation and blunts protective airway reflexes.
Recommendation. Do not combine. If both have been taken together and breathing is slow or shallow, consciousness is impaired, or vomiting occurs, seek emergency medical care immediately.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alcohol and Ketamine are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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