Supplement × Prescription·a conflict·Emerging evidence
St. John's Wort induces drug-metabolizing enzymes and transporters and may lower exposure to some antipsychotics or destabilize psychiatric treatment.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort induces drug-metabolizing enzymes and transporters and may lower exposure to some antipsychotics or destabilize psychiatric treatment.
Mechanism. Enzyme and transporter induction may reduce antipsychotic exposure; independent serotonergic or activating effects may worsen psychiatric symptoms.
Recommendation. Avoid St. John's Wort unless the psychiatric prescriber explicitly approves and clozapine response is monitored closely.
Effect on the composite score
If both Clozapine and St. John's Wort are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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