NutriStack
Coenzyme Q10 Ubiquinol and Levothyroxine, timing-sensitive.
CoQ10 may have a minor effect on levothyroxine absorption if taken concurrently. While the interaction is not well-studied, the general recommendation for levothyroxine is to avoid taking it with any supplement to maximize absorption.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Coenzyme Q10 Ubiquinol and Levothyroxine
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Insufficient
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Insufficient evidence
Timing Sensitive
What is happening. CoQ10 may have a minor effect on levothyroxine absorption if taken concurrently. While the interaction is not well-studied, the general recommendation for levothyroxine is to avoid taking it with any supplement to maximize absorption.
Mechanism. The lipophilic nature of CoQ10 formulations may interfere with levothyroxine absorption in the GI tract. The effect is likely minor but relevant given levothyroxine's narrow therapeutic index.
Recommendation. As a general precaution, separate levothyroxine and CoQ10 by at least 2-4 hours. This is a conservative recommendation given levothyroxine's well-known sensitivity to co-administered substances.
Minimum separation. 240
Sources (2)
- Liwanpo L, Hershman JM. Conditions and drugs interfering with thyroxine absorption. Best Pract Res Clin Endocrinol Metab. 2009;23(6):781-792. PMID 19942153
- Ross DS. Treating hypothyroidism is not always easy: When to treat subclinical hypothyroidism, TSH goals in the elderly, and alternatives to levothyroxine monotherapy. Journal of Internal Medicine. 2022. PMID 34766382
Stack Score
How this pair moves the number.
Effect on the composite score
If both Coenzyme Q10 Ubiquinol and Levothyroxine are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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