What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Amlodipine + Coenzyme Q10 Ubiquinol pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Amlodipine and Coenzyme Q10 Ubiquinol, a synergy.

Q: Can I take Amlodipine and Coenzyme Q10 Ubiquinol together?

Yes. The combination of Amlodipine and Coenzyme Q10 Ubiquinol produces a measurable benefit. Ubiquinol is the reduced, more bioavailable form of CoQ10 and produces the same modest blood-pressure-lowering and endothelial benefits as ubiquinone, often at lower doses. Combined with amlodipine, the additive systolic-pressure reduction is usually beneficial but can occasionally drop blood pressure further than intended in well-controlled patients.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Ubiquinol is the reduced, more bioavailable form of CoQ10 and produces the same modest blood-pressure-lowering and endothelial benefits as ubiquinone, often at lower doses. Combined with amlodipine, the additive systolic-pressure reduction is usually beneficial but can occasionally drop blood pressure further than intended in well-controlled patients.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Amlodipine and Coenzyme Q10 Ubiquinol
Pair type: Synergy
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: +2 to your Stack Score (per scored synergy row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Synergy · Moderate evidence

Synergy

What is happening. Ubiquinol is the reduced, more bioavailable form of CoQ10 and produces the same modest blood-pressure-lowering and endothelial benefits as ubiquinone, often at lower doses. Combined with amlodipine, the additive systolic-pressure reduction is usually beneficial but can occasionally drop blood pressure further than intended in well-controlled patients.

Mechanism. Ubiquinol restores mitochondrial respiration in vascular smooth muscle and endothelium, raising nitric oxide and reducing vascular resistance. These effects add to amlodipine's vasodilation.

Recommendation. Ubiquinol at 50-100 mg/day combined with amlodipine is appropriate for most patients with hypertension or cardiometabolic disease. Monitor blood pressure for 4 weeks after starting and adjust amlodipine with your prescriber if readings drop below your goal.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Amlodipine and Coenzyme Q10 Ubiquinol are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

Check your full routine

One pair was the worked example. NutriStack runs every pair in your stack at once.

Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.

Open the interaction checker →Browse the full research index