NutriStack
D-Mannose and Lactobacillus Rhamnosus, a synergy.
These act through complementary anti-uropathogen mechanisms, pairing bacterial anti-adhesion with competitive colonization to support urinary tract defense.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- D-Mannose and Lactobacillus Rhamnosus
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. These act through complementary anti-uropathogen mechanisms, pairing bacterial anti-adhesion with competitive colonization to support urinary tract defense.
Mechanism. D-Mannose occupies E. coli type 1 fimbrial lectins to prevent urothelial attachment, while Lactobacillus rhamnosus competitively colonizes and lowers pH to inhibit uropathogen growth.
Recommendation. Reasonable to combine for recurrent UTI prophylaxis. No timing constraint required.
Sources (2)
- Kranjcec B, Papes D, Altarac S, D-mannose powder for prophylaxis of recurrent urinary tract infections in women, World Journal of Urology, 2014
- Reid G et al., Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora, FEMS Immunology and Medical Microbiology, 2001
Stack Score
How this pair moves the number.
Effect on the composite score
If both D-Mannose and Lactobacillus Rhamnosus are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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