NutriStack
D-Mannose and Probiotics, a synergy.
D-mannose prevents E. coli adhesion to uroepithelium; probiotics support gut and urogenital flora that resists pathogen colonization.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- D-Mannose and Probiotics
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. D-mannose prevents E. coli adhesion to uroepithelium; probiotics support gut and urogenital flora that resists pathogen colonization.
Mechanism. D-mannose binds FimH adhesin on E. coli; Lactobacillus species produce lactic acid and antimicrobial peptides that inhibit uropathogens.
Recommendation. Combine for recurrent UTI prevention: D-mannose 2 g/day plus L. rhamnosus or reuteri strains.
Sources (1)
- Domenici L et al. D-mannose: a promising support for acute urinary tract infections in women. A pilot study. Eur Rev Med Pharmacol Sci. 2016
Stack Score
How this pair moves the number.
Effect on the composite score
If both D-Mannose and Probiotics are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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