Supplement × Supplement·a caution·Moderate evidence

Deglycyrrhizinated Licorice (DGL) + Potassium

Caution Moderate evidence

True DGL should have low glycyrrhizin, but contaminated or incompletely deglycyrrhizinated products can lower potassium and cause hypertension.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Pair type
Caution
Evidence
Moderate
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionModerate evidence

What is happening. True DGL should have low glycyrrhizin, but contaminated or incompletely deglycyrrhizinated products can lower potassium and cause hypertension.

Mechanism. Residual glycyrrhizin can inhibit 11-beta-HSD2, causing mineralocorticoid effects and potassium wasting.

Recommendation. Use verified DGL and seek medical advice if taking potassium, diuretics, digoxin, or blood pressure medications.

Stack Score

How it moves the number.

Effect on the composite score

If both Deglycyrrhizinated Licorice (DGL) and Potassium are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1NCCIH. Licorice Root: Usefulness and Safety. 2024.Needs sourceNo link

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