Supplement × Supplement·a caution·Emerging evidence
St. John's Wort can alter drug metabolism and complicate hormonal or anticoagulant therapy contexts where dong quai is already risky.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort can alter drug metabolism and complicate hormonal or anticoagulant therapy contexts where dong quai is already risky.
Mechanism. CYP/P-gp induction plus uncertain hormonal and bleeding effects.
Recommendation. Avoid unsupervised multi-herb hormone stacks.
Effect on the composite score
If both Dong Quai and St. John's Wort are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack