From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. L-Theanine may have calming or sedating effects that can add to doxepin.
Mechanism. Potential additive CNS depression and psychomotor slowing.
Recommendation. Use cautiously and avoid combining before driving, working at heights, or using other sedatives.
Stack Score
How it moves the number.
Effect on the composite score
If both Doxepin and L-Theanine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1U.S. National Library of Medicine. Doxepin tablets US Prescribing Information. 2025.Needs sourceNo link