Supplement × Prescription·a conflict·Moderate evidence
St. John's Wort can add serotonergic effects and alter metabolism of many drugs.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort can add serotonergic effects and alter metabolism of many drugs.
Mechanism. Serotonergic effects can increase serotonin toxicity risk, while enzyme induction may reduce or destabilize exposure to co-medications.
Recommendation. Avoid combining with doxepin unless directed by the prescriber.
Effect on the composite score
If both Doxepin and St. John's Wort are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
Check your full routine
Drop your supplements and prescriptions into NutriStack and it runs every pair at once: every interaction, synergy, timing rule, and contraindication, each linked to its primary source.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
NutriStack