NutriStack
Gabapentin and Magnesium Citrate, timing-sensitive.
Magnesium can reduce gabapentin absorption when taken at the same time. A controlled pharmacokinetic study using magnesium oxide found substantially lower gabapentin exposure, which could matter for seizure control or neuropathic pain relief. Magnesium citrate is a different salt, but it still supplies magnesium in the gut, so the same timing precaution is reasonable.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Gabapentin and Magnesium Citrate
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Moderate evidence
Timing Sensitive
What is happening. Magnesium can reduce gabapentin absorption when taken at the same time. A controlled pharmacokinetic study using magnesium oxide found substantially lower gabapentin exposure, which could matter for seizure control or neuropathic pain relief. Magnesium citrate is a different salt, but it still supplies magnesium in the gut, so the same timing precaution is reasonable.
Mechanism. Concomitant magnesium can lower gabapentin intestinal absorption and oral bioavailability. The effect appears to occur in the gut rather than through kidney clearance, so spacing doses reduces the amount of magnesium present during gabapentin absorption.
Recommendation. Separate magnesium citrate from gabapentin by at least 2 hours. Take gabapentin first when possible, then take magnesium later. If seizures or pain worsen after starting magnesium, tell your prescriber because gabapentin exposure may have dropped.
Minimum separation. 120
Sources (2)
- Yagi T, Naito T, Mino Y, Umemura K, Kawakami J. Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects. Drug Metab Pharmacokinet. 2012;27(2):248-254. PMID 22240839
- Yagi T, Naito T, Mino Y, Umemura K, Kawakami J. Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects. Drug Metab Pharmacokinet. 2012;27(2):248-254. PMID 22240839
Stack Score
How this pair moves the number.
Effect on the composite score
If both Gabapentin and Magnesium Citrate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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