NutriStack
Gabapentin and Magnesium Glycinate, timing-sensitive.
Magnesium-containing antacids and supplements reduce gabapentin absorption when taken concurrently. Studies have shown approximately 20% reduction in gabapentin bioavailability, which may reduce its efficacy for pain control or seizure prevention.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Gabapentin and Magnesium Glycinate
- Pair type
- Timing Sensitive
- Evidence (highest tier)
- Moderate
- Source citations
- 5 sources
- Stack Score effect
- −5 to your Stack Score (per scored timing-sensitive row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Timing Sensitive · Moderate evidence
Timing Sensitive
What is happening. Magnesium-containing antacids and supplements reduce gabapentin absorption when taken concurrently. Studies have shown approximately 20% reduction in gabapentin bioavailability, which may reduce its efficacy for pain control or seizure prevention.
Mechanism. Magnesium (particularly in antacid forms) can reduce gabapentin absorption through alteration of local GI pH and potential binding interactions. Gabapentin absorption occurs via the L-amino acid transporter in the small intestine, and its solubility is pH-dependent.
Recommendation. Separate gabapentin and magnesium supplements by at least 2 hours. Take gabapentin at least 2 hours after magnesium to ensure adequate absorption.
Minimum separation. 120
Sources (5)
- Yagi T, Naito T, Mino Y, Umemura K, Kawakami J. Impact of concomitant antacid administration on gabapentin plasma exposure and oral bioavailability in healthy adult subjects. Drug Metab Pharmacokinet. 2012;27(2):248-254. PMID 22240839
- Busch JA et al. The effect of antacids on gabapentin pharmacokinetics. Epilepsia. 1997;38(Suppl 3):72. PMID 9234576
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Gabapentin and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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