What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Lansoprazole + Magnesium Glycinate pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Lansoprazole and Magnesium Glycinate, a caution.

Q: Can I take Lansoprazole and Magnesium Glycinate together?

Possibly, but with caution. Lansoprazole and Magnesium Glycinate have a documented caution-tier interaction. Lansoprazole, like other PPIs, can cause hypomagnesemia after months to years of use. Case reports and meta-analyses confirm reduced intestinal magnesium uptake on long-term PPIs, with episodes of seizure, tetany, and arrhythmia documented even in patients on oral magnesium. Symptoms typically resolve only after the PPI is stopped.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Lansoprazole, like other PPIs, can cause hypomagnesemia after months to years of use. Case reports and meta-analyses confirm reduced intestinal magnesium uptake on long-term PPIs, with episodes of seizure, tetany, and arrhythmia documented even in patients on oral magnesium. Symptoms typically resolve only after the PPI is stopped.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Lansoprazole and Magnesium Glycinate
Pair type: Caution
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Strong evidence

Caution

What is happening. Lansoprazole, like other PPIs, can cause hypomagnesemia after months to years of use. Case reports and meta-analyses confirm reduced intestinal magnesium uptake on long-term PPIs, with episodes of seizure, tetany, and arrhythmia documented even in patients on oral magnesium. Symptoms typically resolve only after the PPI is stopped.

Mechanism. PPI-induced hypochlorhydria impairs active intestinal magnesium uptake by TRPM6/TRPM7 channels, which depend on luminal proton gradients. The defect is class-wide and reverses within days of discontinuation.

Recommendation. Check serum magnesium at baseline and at least annually on long-term lansoprazole. If low, start magnesium glycinate and discuss whether the PPI can be switched to an H2 blocker or stopped.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Lansoprazole and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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