NutriStack
Magnesium Glycinate and Omeprazole, a caution.
Long-term omeprazole use (>1 year) has been associated with clinically significant magnesium depletion (hypomagnesemia). The FDA issued a safety communication in 2011 warning about this risk. Symptoms include muscle cramps, tremors, seizures, and cardiac arrhythmias.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Magnesium Glycinate and Omeprazole
- Pair type
- Caution
- Evidence (highest tier)
- Strong
- Source citations
- 6 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Strong evidence
Caution
What is happening. Long-term omeprazole use (>1 year) has been associated with clinically significant magnesium depletion (hypomagnesemia). The FDA issued a safety communication in 2011 warning about this risk. Symptoms include muscle cramps, tremors, seizures, and cardiac arrhythmias.
Mechanism. PPIs impair active intestinal magnesium absorption via TRPM6 and TRPM7 channels in the distal small intestine and colon. Chronic acid suppression alters the electrochemical gradient needed for magnesium transport, leading to progressive depletion over months to years.
Recommendation. Monitor magnesium levels periodically if on long-term omeprazole therapy. Consider magnesium supplementation (200-400mg/day), particularly if experiencing muscle cramps or fatigue. Discuss with your prescriber.
Sources (6)
- Hess MW et al. Systematic review: hypomagnesaemia induced by proton pump inhibition. Aliment Pharmacol Ther. 2012;36(5):405-413. PMID 22762246
- Park CH, Kim EH, Roh YH, Kim HY, Lee SK. Proton pump inhibitors linked to hypomagnesemia: a systematic review and meta-analysis of observational studies. Ren Fail. 2015;37(7):1237-1241. PMID 26108134
- Choudhury A, Jena A, Jearth V, Dutta AK et al.. Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis. Expert Review of Gastroenterology & Hepatology. 2023. PMID 37060552
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Magnesium Glycinate and Omeprazole are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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