NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Omeprazole

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

A widely prescribed proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, and Zollinger-Ellison syndrome. Omeprazole reduces stomach acid production and allows healing of acid-damaged tissue in the GI tract.

Evidence tier
Strong
Indexed sources
12 2001–2025
Interactions
0
Depletes
4 nutrients
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

A widely prescribed proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, and Zollinger-Ellison syndrome. NutriStack rates the supporting evidence as strong. Common adult dosing is 20–40 mg once daily for 4–8 weeks; maintenance 20 mg/day (as prescribed by your physician), though a prescriber sets the actual dose. With long-term use it can deplete magnesium, vitamin b12, calcium. This profile indexes 12 sources.

What it's good for
  • Heals erosive esophagitis4,1
  • Relieves GERD symptoms (heartburn, regurgitation)1,4
  • Treats and prevents peptic ulcers
  • Eradicates H. pylori (as part of combination therapy)10
  • Reduces risk of NSAID-associated gastric ulcers2,5
What to watch for
  • Headache
  • Nausea
  • Diarrhea
  • Known hypersensitivity to omeprazole or other PPIs1,3
  • Concurrent use with rilpivirine-containing products

The bottom line

Evidence rating strong. Most-documented uses: heals erosive esophagitis, relieves gerd symptoms (heartburn, regurgitation), treats and prevents peptic ulcers. 12 sources indexed (2001–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Irreversibly inhibits the hydrogen/potassium ATPase (H+/K+ ATPase) proton pump on the luminal surface of gastric parietal cells. By covalently binding to cysteine residues on the pump, omeprazole blocks the final step of acid secretion, reducing basal and stimulated gastric acid output by up to 95%.1,2

Class
Proton Pump Inhibitor
Absorption
Best on an empty stomach
Dosing

Dosing & protocol.

Common range
20–40 mg once daily for 4–8 weeks; maintenance 20 mg/day (as prescribed by your physician)
Recommended form
Delayed-release capsule or oral suspension

Take 30–60 minutes before the first meal of the day for optimal acid suppression

Depletions

What it depletes.

Nutrients this medication can lower over time, and what to replace.

Magnesium

Significant

Chronic acid suppression impairs active intestinal magnesium transport, especially via TRPM6/7-mediated uptake.

Replace Magnesium GlycinateMonitor Serum magnesium or RBC magnesiumOnset Most often after >1 year of regular use

Vitamin B12

Moderate

Reduced gastric acid impairs release of food-bound vitamin B12 from proteins, lowering long-term absorption.

Replace MethylcobalaminMonitor Serum B12 + methylmalonic acidOnset Most evident after >1-2 years of regular use

Calcium

Moderate

Lower gastric acidity reduces dissolution and absorption of less-soluble calcium salts, especially calcium carbonate.

Replace CalciumMonitor Serum calcium or bone density trendOnset Gradual effect with long-term use

Iron

Moderate

Reduced gastric acidity lowers conversion and solubility of non-heme iron, decreasing long-term absorption.

Replace Iron BisglycinateMonitor Ferritin + transferrin saturationOnset Gradual effect with long-term use

Full Omeprazole depletion and interaction guide →

Safety

Full safety detail.

Side effects

  • Headache
  • Nausea
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Vitamin B12 deficiency with long-term use
  • Hypomagnesemia with prolonged use
  • Increased risk of C. difficile infection
  • Increased risk of bone fractures (hip, wrist, spine) with long-term use

Contraindications

  • Known hypersensitivity to omeprazole or other PPIs1,3
  • Concurrent use with rilpivirine-containing products
  • Concurrent use with nelfinavir
  • Patients with osteoporosis risk factors on long-term therapy (use with caution)2,8
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

3

Randomized controlled trials

1

Reviews & position papers

3

Reference material

5
FAQ

Common questions.

Quick answers about Omeprazole, drawn from the data on this page.

What is Omeprazole?

A widely prescribed proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD), peptic ulcers, erosive esophagitis, and Zollinger-Ellison syndrome. Omeprazole reduces stomach acid production and allows healing of acid-damaged tissue in the GI tract.

What is Omeprazole used for?

Commonly cited benefits of Omeprazole include: Heals erosive esophagitis; Relieves GERD symptoms (heartburn, regurgitation); Treats and prevents peptic ulcers; Eradicates H. pylori (as part of combination therapy); Reduces risk of NSAID-associated gastric ulcers. NutriStack rates the overall evidence as strong.

What is a typical dose of Omeprazole?

A typical adult dose of Omeprazole is 20–40 mg once daily for 4–8 weeks; maintenance 20 mg/day (as prescribed by your physician). The commonly recommended form is Delayed-release capsule or oral suspension. These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Omeprazole?

Reported side effects include headache, nausea, diarrhea, abdominal pain, flatulence, vitamin b12 deficiency with long-term use. This is educational information; check with a healthcare professional before use.

How strong is the evidence for Omeprazole?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Omeprazole in NutriStack.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.