NutriStack
Digoxin and Magnesium Glycinate, a caution.
Hypomagnesemia increases sensitivity to digoxin toxicity by altering the cardiac sodium-potassium ATPase that digoxin inhibits. Maintaining adequate magnesium levels is important for preventing digoxin-related cardiac arrhythmias. Many patients on digoxin also take diuretics that deplete magnesium.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Digoxin and Magnesium Glycinate
- Pair type
- Caution
- Evidence (highest tier)
- Strong
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Strong evidence
Caution
What is happening. Hypomagnesemia increases sensitivity to digoxin toxicity by altering the cardiac sodium-potassium ATPase that digoxin inhibits. Maintaining adequate magnesium levels is important for preventing digoxin-related cardiac arrhythmias. Many patients on digoxin also take diuretics that deplete magnesium.
Mechanism. Magnesium normally competes with digoxin for binding to the Na+/K+-ATPase. When magnesium is depleted, digoxin binding affinity increases, potentiating its inhibitory effect on the sodium-potassium pump. This increases intracellular calcium and the risk of digoxin-induced cardiac arrhythmias.
Recommendation. Monitor magnesium levels regularly while on digoxin. Maintain adequate magnesium intake through supplementation if needed (200-400mg/day). Be especially vigilant if also taking diuretics that deplete magnesium.
Sources (4)
- Eichhorn EJ, Gheorghiade M. Digoxin--new perspective on an old drug. N Engl J Med. 2002;347(18):1394-1395. PMID 12409540
- Mah J, Pitre T. Oral magnesium supplementation for insomnia in older adults: a Systematic Review & Meta-Analysis.. BMC Complementary Medicine and Therapies. 2021. PMID 33865376
- Veronese N, Dominguez LJ, Pizzol D et al.. Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials.. Nutrients. 2021. PMID 34836329
- Veronese N, Pizzol D, Smith L et al.. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials.. Nutrients. 2022. PMID 35277037
Stack Score
How this pair moves the number.
Effect on the composite score
If both Digoxin and Magnesium Glycinate are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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