NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Digoxin and Potassium: what the published research says

PubMed indexes 4 records that name Digoxin and Potassium together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Digoxin and Potassium. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Digoxin and Potassium.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Impact of Abnormal Potassium on Arrhythmia Risk During Pediatric Digoxin Therapy.

Pediatric cardiology · 2024 · PMID 36403164

ReviewHuman subjects171 participants

“Odds of arrhythmia is increased during digoxin administration when pediatric patients have abnormal potassium levels. Vigilant attention to potassium levels is essential to prevent adverse outcomes during digoxin therapy.”

Mlambo et al. · From the abstract

Names both Digoxin and Potassium in its title.

Interactions between digoxin and potassium-sparing diuretics.

Clinical pharmacology and therapeutics · 1983 · PMID 6831820

Human subjects

“The results indicate a drug-receptor interaction between spironolactone metabolites and digoxin at the hypothetical inotropic digitalis receptor. Amiloride has been reported to suppress digoxin inotropism, whereas spironolactone induces minor inhibition and triamterene does not affect digoxin inotropism.”

Waldorff et al. · From the abstract

Names both Digoxin and Potassium in its title.

Prevalence of Drug-Drug Interactions in Older Community-Dwelling Individuals: A Systematic Review and Meta-analysis.

Drugs & aging · 2023 · PMID 36692678

Meta-AnalysisSystematic ReviewHuman subjects

“DDIs are prevalent among older community-dwelling individuals; however, the methodology used to estimate these events varies considerably. A standardised methodology is needed to allow meaningful measurement and comparison of DDI prevalence.”

Hughes et al. · Authors' conclusion

Names Digoxin and Potassium together in an interaction, co-administration, or pharmacokinetic context.

A population pharmacokinetic-pharmacodynamic analysis and model validation of azimilide.

Clinical pharmacology and therapeutics · 2001 · PMID 11673753

Meta-AnalysisHuman subjects

“Azimilide PK parameters are dependent on body weight, gender, smoking status, and bilirubin and are independent of the coadministration of digoxin, warfarin, and cytochrome P4503A4 inhibitors and inducers. The relationship between azimilide concentration and change in QTc is primarily dependent on serum potassium.”

Phillips et al. · Authors' conclusion

Names Digoxin and Potassium together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Digoxin, Potassium, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.