Supplement × Prescription·a caution·Emerging evidence
St. John's Wort induces CYP3A4 and may lower exposure to drugs with CYP3A4 metabolism, including galantamine.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. St. John's Wort induces CYP3A4 and may lower exposure to drugs with CYP3A4 metabolism, including galantamine.
Mechanism. CYP3A4 induction may increase galantamine metabolism and reduce therapeutic exposure.
Recommendation. Avoid unless the prescriber reviews the interaction and monitors cognitive or functional response.
Effect on the composite score
If both Galantamine and St. John's Wort are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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