NutriStack
Ibuprofen and Nattokinase, a caution.
Nattokinase has fibrinolytic and anticoagulant effects that may add to ibuprofen-related bleeding risk. Ibuprofen can irritate the GI tract and transiently impair platelet function. The combination is most concerning with high-dose nattokinase, repeated ibuprofen use, prior ulcers, surgery, or other blood-thinning medicines.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Ibuprofen and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Nattokinase has fibrinolytic and anticoagulant effects that may add to ibuprofen-related bleeding risk. Ibuprofen can irritate the GI tract and transiently impair platelet function. The combination is most concerning with high-dose nattokinase, repeated ibuprofen use, prior ulcers, surgery, or other blood-thinning medicines.
Mechanism. Nattokinase promotes fibrinolysis and has been shown to affect coagulation and platelet-related thrombus formation. Ibuprofen adds COX-1-mediated platelet effects and NSAID mucosal injury, reducing hemostatic reserve.
Recommendation. Avoid nattokinase while using ibuprofen regularly. Stop nattokinase at least 1-2 weeks before procedures unless your clinician gives different instructions, and seek care for bleeding symptoms.
Sources (2)
- Kurosawa Y, Nirengi S, Homma T, Esaki K, Ohta M, Clark JF, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015;5:11601. PMID 26109079
- Sostres C, Gargallo CJ, Arroyo MT, Lanas A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. Best Pract Res Clin Gastroenterol. 2010;24(2):121-132. PMID 20227026
Stack Score
How this pair moves the number.
Effect on the composite score
If both Ibuprofen and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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