NutriStack
Aspirin and Nattokinase, a caution.
Documented cerebellar hemorrhage from nattokinase + aspirin after only 7 days. Both inhibit platelet aggregation via thromboxane blockade.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Aspirin and Nattokinase
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Documented cerebellar hemorrhage from nattokinase + aspirin after only 7 days. Both inhibit platelet aggregation via thromboxane blockade.
Mechanism. Both block thromboxane-mediated platelet aggregation. Additive antithrombotic effect increases hemorrhage risk.
Recommendation. Do NOT combine without medical supervision. Higher risk in patients with cerebral microbleeds.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Aspirin and Nattokinase are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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