NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Alcohol and Ibuprofen: what the published research says

PubMed indexes 4 records that name Alcohol and Ibuprofen together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Alcohol and Ibuprofen. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

4 studies naming Alcohol and Ibuprofen.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Ibuprofen-loaded electrospun poly(ethylene-co-vinyl alcohol) nanofibers for wound dressing applications.

Nanoscale advances · 2023 · PMID 37056625

“Additionally, at 25 °C less drug was released when the ethylene content of the membranes increased. Finally, the scaffolds showed no cytotoxicity to normal human fibroblasts collectively paving the way for the design of electrospun based patches for the treatment of chronic wounds.”

Schoeller et al. · From the abstract

Names both Alcohol and Ibuprofen in its title.

In-Silico Screening of Lipid-Based Drug Delivery Systems.

Pharmaceutical research · 2020 · PMID 33230602

Comparative Study

“The API solubility individually depends on the choice of excipients. The proposed in-silico-screening approach allows formulators to quickly determine most-appropriate types of lipid-based formulations for a given API with low experimental effort. Graphical abstract.”

Brinkmann et al. · Authors' conclusion

Names Alcohol and Ibuprofen together in an interaction, co-administration, or pharmacokinetic context.

Pharmacokinetics and bioavailability of percutaneous ibuprofen.

Arzneimittel-Forschung · 1995 · PMID 8595072

Clinical TrialComparative StudyRandomized Controlled Trial

“The surprisingly high levels of ibuprofen found in the plasma after percutaneous application are still below the threshold where systemic side effects might be expected (10 micrograms/ml). The high peak plasma concentration and relative bioavailability of percutaneous ibuprofen are likely due to the galenical formation of the gel preparation, which contains isopropyl alcohol and propylene glycol as co-solvents and is adjusted to pH 5, and to the use of occlusion.”

Kleinbloesem et al. · From the abstract

Names Alcohol and Ibuprofen together in an interaction, co-administration, or pharmacokinetic context.

Pharmacokinetic interactions of alcohol and acetylsalicylic acid.

European journal of clinical pharmacology · 1995 · PMID 7589030

Clinical TrialRandomized Controlled Trial

“Plasma concentrations of ethanol were measured by gas chromatography, and those of the drugs by liquid chromatography. There was no effect of ASA, ibuprofen or paracetamol on the single-dose kinetics of ethanol, but concurrent intake of ethanol reduced the peak concentration of ASA by 25%.”

Melander et al. · From the abstract

Names Alcohol and Ibuprofen together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Alcohol, Ibuprofen, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.