What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Icosapent Ethyl + Vitamin K1 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Insufficient evidence

Icosapent Ethyl + Vitamin K1

Q: Can I take Icosapent Ethyl and Vitamin K1 together?

Yes, if you separate them in time. Icosapent Ethyl and Vitamin K1 have a documented timing-sensitive interaction. Icosapent ethyl is a fatty acid ester that requires dietary fat for absorption, and fat-soluble vitamin K1 is similarly best absorbed with a fat-containing meal. Taking them together with food can optimize absorption of both, though there is no harmful interaction.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Insufficient evidence

Icosapent ethyl is a fatty acid ester that requires dietary fat for absorption, and fat-soluble vitamin K1 is similarly best absorbed with a fat-containing meal. Taking them together with food can optimize absorption of both, though there is no harmful interaction.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Icosapent Ethyl and Vitamin K1

Pair type

Timing Sensitive

Evidence

Insufficient

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveInsufficient evidence

What is happening. Icosapent ethyl is a fatty acid ester that requires dietary fat for absorption, and fat-soluble vitamin K1 is similarly best absorbed with a fat-containing meal. Taking them together with food can optimize absorption of both, though there is no harmful interaction.

Mechanism. Both icosapent ethyl (an omega-3 ethyl ester) and vitamin K1 (a fat-soluble vitamin) rely on bile-acid-dependent micellar solubilization and dietary fat for intestinal absorption. Co-ingestion with fat enhances uptake of both; the interaction is one of shared absorption physiology rather than direct chemical interference.

Recommendation. Take icosapent ethyl with food as directed. If you supplement vitamin K1, taking it with the same fat-containing meal is reasonable. If you also take warfarin, keep your vitamin K intake consistent and discuss any changes with your clinician.

Stack Score

How it moves the number.

Effect on the composite score

If both Icosapent Ethyl and Vitamin K1 are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Amarin Pharma. Vascepa (icosapent ethyl) Prescribing Information. 2019.Needs sourceNo link
2Shearer MJ, Newman P. Metabolism and cell biology of vitamin K. Thromb Haemost. 2008.Needs sourceNo link

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