What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Iron + Oligonol (Lychee Polyphenol) pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·timing-sensitive·Moderate evidence

Iron + Oligonol (Lychee Polyphenol)

Q: Can I take Iron and Oligonol (Lychee Polyphenol) together?

Yes, if you separate them in time. Iron and Oligonol (Lychee Polyphenol) have a documented timing-sensitive interaction. Like other proanthocyanidin-rich polyphenols, Oligonol can bind non-heme iron in the gut and reduce its absorption when taken at the same time, which is relevant for people supplementing iron for deficiency.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Moderate evidence

Like other proanthocyanidin-rich polyphenols, Oligonol can bind non-heme iron in the gut and reduce its absorption when taken at the same time, which is relevant for people supplementing iron for deficiency.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Iron and Oligonol (Lychee Polyphenol)

Pair type

Timing Sensitive

Evidence

Moderate

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

Timing SensitiveModerate evidence

What is happening. Like other proanthocyanidin-rich polyphenols, Oligonol can bind non-heme iron in the gut and reduce its absorption when taken at the same time, which is relevant for people supplementing iron for deficiency.

Mechanism. Polyphenols chelate ferric iron and form insoluble complexes in the intestinal lumen, lowering non-heme iron bioavailability when co-ingested.

Recommendation. Separate Oligonol and iron supplements by about 2 hours. Take iron on an empty stomach or with vitamin C, and Oligonol at a different time of day.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Iron and Oligonol (Lychee Polyphenol) are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Hurrell RF, Reddy M, Cook JD. Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages. British Journal of Nutrition. 1999.Needs sourceNo link

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