What kind of interaction is it?

Synergy: a documented combination effect that is stronger or more useful than either substance taken alone.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the L-Citrulline + Oligonol (Lychee Polyphenol) pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Supplement·a synergy·Emerging evidence

L-Citrulline + Oligonol (Lychee Polyphenol)

Q: Can I take L-Citrulline and Oligonol (Lychee Polyphenol) together?

Yes. The combination of L-Citrulline and Oligonol (Lychee Polyphenol) produces a measurable benefit. L-Citrulline raises plasma arginine and nitric oxide production while Oligonol supports endothelial function and microcirculation; combined use may give additive support to peripheral blood flow.

Q: How does this affect a NutriStack Stack Score?

+2 to your Stack Score per scored synergy row.

Synergy Emerging evidence

L-Citrulline raises plasma arginine and nitric oxide production while Oligonol supports endothelial function and microcirculation; combined use may give additive support to peripheral blood flow.

Supplement × Supplement

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

L-Citrulline and Oligonol (Lychee Polyphenol)

Pair type

Synergy

Evidence

Emerging

Source citations

Scope

Supplement × Supplement

Last verified

June 4, 2026

SynergyEmerging evidence

What is happening. L-Citrulline raises plasma arginine and nitric oxide production while Oligonol supports endothelial function and microcirculation; combined use may give additive support to peripheral blood flow.

Mechanism. L-Citrulline boosts the arginine-NO substrate supply while Oligonol's antioxidant action may preserve nitric oxide bioavailability, jointly favoring vasodilation.

Recommendation. Reasonable to combine for circulation or exercise blood-flow goals. Monitor for any additive blood-pressure lowering if also on antihypertensives.

Stack Score

How it moves the number.

Effect on the composite score

If both L-Citrulline and Oligonol (Lychee Polyphenol) are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Nishizawa M, et al. Effects of Oligonol on vascular and circulatory parameters in humans. Clinical study. 2011.Needs sourceNo link

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One pair was the worked example.

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Open the interaction checker → Browse the research index