What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 1 citation row for the Iron + Quinapril pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Emerging evidence

Iron + Quinapril

Q: Can I take Iron and Quinapril together?

Yes, if you separate them in time. Iron and Quinapril have a documented timing-sensitive interaction. Oral iron salts can chelate ACE inhibitors in the gastrointestinal tract, and quinapril's magnesium carbonate formulation may also reduce iron absorption when taken together. Co-administration risks lowering the bioavailability of both agents. Data are clearer for related ACE inhibitors, but the chelation mechanism is shared.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Emerging evidence

Oral iron salts can chelate ACE inhibitors in the gastrointestinal tract, and quinapril's magnesium carbonate formulation may also reduce iron absorption when taken together. Co-administration risks lowering the bioavailability of both agents. Data are clearer for related ACE inhibitors, but the chelation mechanism is shared.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Iron and Quinapril

Pair type

Timing Sensitive

Evidence

Emerging

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveEmerging evidence

What is happening. Oral iron salts can chelate ACE inhibitors in the gastrointestinal tract, and quinapril's magnesium carbonate formulation may also reduce iron absorption when taken together. Co-administration risks lowering the bioavailability of both agents. Data are clearer for related ACE inhibitors, but the chelation mechanism is shared.

Mechanism. Ferrous and ferric cations form insoluble chelates with ACE inhibitors and with the carbonate excipients in quinapril, reducing gastrointestinal absorption of both the drug and the iron.

Recommendation. Separate oral iron supplements from quinapril by at least 2 hours. Monitor blood pressure and, if treating iron deficiency, recheck iron studies to confirm adequate response.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

120

Stack Score

How it moves the number.

Effect on the composite score

If both Iron and Quinapril are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1Campbell NR, Hasinoff BB. Iron supplements: a common cause of drug interactions. Br J Clin Pharmacol. 1991.Needs sourceNo link

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One pair was the worked example.

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Open the interaction checker → Browse the research index