Supplement × Prescription·a caution·Moderate evidence
Magnesium Glycinate may add to the blood-pressure-lowering effect of Quinapril.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Magnesium Glycinate may add to the blood-pressure-lowering effect of Quinapril.
Mechanism. Additive vasodilation, nitric oxide signaling, or smooth-muscle relaxation can lower blood pressure further.
Recommendation. Monitor blood pressure and dizziness, especially during dose changes; stop the supplement and seek advice if syncope, falls, or symptomatic hypotension occurs.
What is happening. Quinapril tablets contain magnesium carbonate as an excipient, and concurrent magnesium- or aluminum-containing antacids (and to a lesser extent oral magnesium supplements taken at the same time) can reduce quinapril absorption by forming poorly soluble chelates in the gut, potentially lowering its blood-pressure-lowering effect. The interaction is well documented for magnesium-containing antacids; separating administration restores absorption.
Mechanism. Divalent magnesium cations can chelate quinapril in the gastrointestinal tract, forming insoluble complexes that decrease the fraction of drug absorbed; reduced bioavailability may blunt antihypertensive efficacy.
Recommendation. Separate oral magnesium supplements from quinapril by at least 2 hours to minimize any reduction in drug absorption. Take quinapril consistently with respect to meals and monitor blood pressure if you begin or change magnesium dosing.
Space the doses apart by at least this window to avoid the conflict.
Effect on the composite score
If both Magnesium Glycinate and Quinapril are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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